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ftsE [2018-02-10T10:58:15.000Z]
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ftsE [2018-02-10T10:58:15.000Z]

ABC transporter (ATP-binding protein) (FtsE-FtsX), required for CwlO activity (cell elongation) and for proper activation of Spo0A and initiation of sporulation
Locus
BSU35260
Isoelectric point
8.42
Molecular weight
25.47 kDa
Protein length
228 aa Sequence Blast
Gene length
684 bp Sequence Blast
Function
Product
ABC transporter (ATP-binding protein)
Essential
no
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
3,624,821 → 3,625,507

Phenotypes of a mutant

  • a ftsE mutation is synthetically lethal with a lytE mutation (due to a lack of autolysin activity) PubMed
  • shorter, fatter cells, this can be rescued by addition of Mg(2+) PubMed
  • reduced growth rate, especially at low Mg(2+) concentrations PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • necessary for the autolysin activity of CwlO PubMed
  • Protein family

  • ABC transporter family (according to Swiss-Prot)
  • Paralogous protein(s)

    Structure

  • 3TIF (ATP-binding protein from Methanococcus jannaschii, 40% identity) PubMed
  • Localization

  • membrane associated (via FtsX) PubMed
  • Expression and Regulation

    Operons

    Genes
    Description
    (according to DBTBS) null

    Regulatory mechanism

  • Spo0A: repression, PubMed, in Spo0A regulon
  • Regulation

  • repressed under conditions that trigger sporulation (Spo0A) PubMed
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    Biological materials

    Mutant

  • BKE35260 (ΔftsE::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGAAATCACCTAATCTTT, downstream forward: _UP4_GAGTCAAGAGGGGAGTATGG
  • BKK35260 (ΔftsE::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGAAATCACCTAATCTTT, downstream forward: _UP4_GAGTCAAGAGGGGAGTATGG
  • References

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